Cenforce 25 mg (which contains sildenafil citrate) can interact with several medications and substances. It’s important to be aware of these interactions to avoid potentially serious side effects. Here are the main categories of drugs and substances that can interact with Cenforce 25 mg: 1. Nitrates Common Nitrate Drugs: Nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, and other nitrate-based medications used for chest pain or heart conditions. Interaction: Combining sildenafil with nitrates can cause a severe drop in blood pressure, which may lead to dizziness, fainting, heart attack, or stroke. Cenforce 25 mg combination should be avoided at all costs. 2. Alpha-blockers Common Alpha-blockers: Doxazosin, tamsulosin, alfuzosin, prazosin, etc. Interaction: These medications are used to treat high blood pressure or benign prostatic hyperplasia (BPH). Sildenafil can enhance the blood pressure-lowering effects of alpha-blockers, leading to dizziness, lightheadedness, or fainting. 3. Antihypertensive Medications Common Medications: Beta-blockers, calcium channel blockers, ACE inhibitors, etc. Interaction: Sildenafil can further lower blood pressure when taken with antihypertensive drugs, which could cause symptoms like dizziness or fainting, especially when standing up suddenly.