Kamagra Polo over time can be noticed by different people based on a variety of factors. Typically, erectile dysfunction (ED) medications like Kamagra Polo (which contains Sildenafil Citrate) are very effective, but several aspects can influence how well they work. Here's who might notice a reduction in effectiveness: 1. Long-Term Users (Tolerance Development) Men using Kamagra Polo regularly for long periods may develop a form of tolerance. While tolerance to PDE5 inhibitors like Sildenafil is not commonly seen, it can happen in some cases, especially if the medication is being used too frequently or in higher Kamagra Polo than recommended. If you've been using Kamagra Polo for months or years, and feel it’s becoming less effective, this could be due to tolerance. However, this is rare and usually more common in substances where the body adjusts over time. 2. People with Changing Health Conditions Underlying health conditions can affect how well Kamagra Polo works over time. Conditions like diabetes, high blood pressure, heart disease, and hormonal imbalances (such as low testosterone) can diminish the effectiveness of erectile dysfunction medications. Blood circulation plays a key role in how Kamagra Polo works, and if your cardiovascular health worsens, the medication might not have the same effect. For example, if someone has diabetes and their condition is not well-controlled, it can lead to more severe ED, making Kamagra less effective over time. 3. Older Adults Age-related changes in health, such as reduced circulation, lower testosterone levels, and slower metabolism, can make ED treatments like Kamagra Polo less effective. As men age, the body’s response to medications might change, requiring a dose adjustment or a different treatment. In older men, especially those with multiple health issues, the body might metabolize the drug differently, leading to a perceived reduced effectiveness.