Poxet 90 mg contains Dapoxetine, which is used for premature ejaculation, not erectile dysfunction. When considering safety for kidney (renal) patients, there are important points: Kidney Considerations: Metabolism & Excretion: Dapoxetine is metabolized mainly in the liver and excreted via urine and feces. Mild to moderate kidney impairment usually does not require a dose adjustment. Severe Kidney Disease: In patients with severe renal impairment (creatinine clearance <30 mL/min), Poxet 90 mg is generally not recommended. The risk of side effects such as dizziness, fainting, or low blood pressure may be higher. Blood Pressure Effects: Dapoxetine can rarely cause dizziness or fainting, especially Poxet 90 mg standing quickly (orthostatic hypotension). Kidney patients may be more sensitive to these effects, especially if on antihypertensive medications. Other Precautions: Avoid Poxet if taking MAO inhibitors, thioridazine, or certain SSRIs. Start at lower doses (30 mg) and only increase under medical supervision if tolerated. Summary: Mild to moderate kidney impairment: Poxet 90 mg may be used with caution, preferably under medical supervision. Severe kidney impairment: Not recommended due to increased risk of adverse effects. If you want, I can make a safety chart for all ED and premature ejaculation medications you’ve asked about, showing kidney and liver considerations, blood pressure effects, and typical side effects, which would make it very easy to compare them for patients with renal or liver issues.